Vascular integration in tissue bioengineering to model the complexity of leukemic microenvironment

Summury :

We investigate the dynamic interactions between leukemic cells and their vascular microenvironment. Combining in vivo imaging, humanized 3D models, and multi-omics approaches, we explore how the niche contributes to leukemia progression, treatment resistance, and immune evasion, particularly in the bone marrow and central nervous system.