Lung cancer metabolism and bioenergetic precision medicine -Pavillon 1

Our INSERM laboratory investigates the regulation of energy metabolism in physiology and pathology. In particular, the multi-omic molecular analysis of the metabolic reprogramming of human lung tumors revealed novel mechanisms of bioenergetic regulation.

More specifically, we identified two subgroups of human lung adenocarcinomas reflected in the histologically normal-paired cancer-adjacent tissue: high (OX+) mitochondrial respiration and low (OX-) mitochondrial respiration. Then, we provided proof-of-concept data for preclinical precision bioenergetic medicine of oxidative lung carcinomas. Additional work demonstrated that tobacco-specific nitrosamines activate mitochondrial redox signalling to promote lung tumor growth. These malignant properties were acquired by the upregulation and activation of the beta-adrenergic receptor (β2-AR)-nicotinic acetylcholine receptor subunit alpha-7 (CHRNAα7)-dependent nitrosamine canonical signalling pathway.

Altogether, our findings provide knowledge in the field of metabolic regulation, REDOX biology and human lung cancer bioenergetics with medical implication for cancer diagnosis and treatment.