Seminar cancelled: Extracellular vesicle subtypes, non vesicular extracellular particles, and cancer-immune system crosstalk.

Summary

All cells release different types of extracellular vesicles (EVs) representing meaningful packets of cargoes which cells use to exchange information. However, EVs are heterogeneous, in particular including multivesicular endosome-derived exosomes and plasma membrane-derived ectosomes. Deciphering the respective functions of different EV subtypes and of the co-isolated non-vesicular extracellular factors has been the aim of my team for the last decade. We explore this question in the context of communication between tumors and the immune system. I will present our recent results on tumor-derived EV subtypes and their effects on myeloid cells.

Biography

Dr. Clotilde Théry is an INSERM director of research working at Institut Curie, where she heads the team “Extracellular Vesicles, Immune responses and Cancer” (https://institut-curie.org/team/thery) within the “Immunity and Cancer” department (INSERM U932), and the EV-dedicated core facility (https://institut-curie.org/platform/curiecoretech-extracellular-vesicles).

Since 1998, her scientific interests have focused on the study of exosomes, and more recently extracellular vesicles in general, secreted by immune and tumor cells, and their roles in communications between tumors and the immune system. Her goals are to understand the physiological functions of EV secretion during an in vivo immune response and during tumor growth, and her approach is to continuously go from basic cell biology questions on their modes of formation to application of this knowledge to in vivo situations.

C. Théry is regularly invited to write reviews on the subject of exosomes, EVs, their immune functions and their biogenesis. She has organized several symposia and sessions dedicated to exosomes in international meetings, and in particular a first “International Workshop on Exosomes” in Institut Curie, in Paris, in 2011, which led to the creation of the International Society for Extracellular Vesicles (ISEV), for which she served as Secretary General from 2012 to 2016, and more recently President (2020-2022). She has been Editor in Chief of the journal of the Society, J Extracell Vesicles, from its creation in 2012 until 2019. In addition to publishing numerous original articles and reviews on this topic, she has led the community-based efforts to standardization and reproducibility of EV research, which resulted in the MISEV2018 and more recently MISEV2023 guideline articles.