Par : Ivo GOMPERTS BONECA
Date : jeudi 30 septembre 2021
13:30 - 14:30
Lieu : Visioconférence
His research can be separated in two complementary subjects: 1) the study of peptidoglycan (PG) metabolism and its role in cell physiology and antibiotic resistance, and 2) the role that cell wall, and in particular, PG metabolism has on host-microbe interactions. In particular on this last aspect, he is interested in studying the effects of PG as a signaling molecule on host physiology. The PG is constantly released by the gut commensal flora and transported systemically in the host. Some of the effects are local on the gut homeostasis but others occur at distant tissues and organs. The brain is such an organ where the PG can be found exclusively after oral but not after systemic administration. We show that the process is dependent on a mature microbiota, on the parasympathetic system and partially mediated by exosomes.
1. Dias Bastos PA, R Wheeler, IG Boneca. 2021. Uptake, recognition and responses to peptidoglycan in the mammalian host. FEMS Microbiol Rev. 45(1):fuaa044.
2. Macho Fernandez E, V Valenti, C Rockel, C Hermann, B Pot, IG Boneca,C Grangette. 2011. Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut. 60(8):1050-1059.
3. Bouskra D, C Brézillon, M Bérard, C Werts, R Varona, IG Boneca, G Eberl. 2008. Lymphoid tissue genesis induced by bacterial commensals through NOD1 and β-defensin regulates intestinal homeostasis. Nature. 456(7221):507-510.