Impact of spindle assembly checkpoint activity on chromosome instability and therapeutic response of colorectal cancer stem cells

Ilio Vitale is mainly interested in the links between cancer stemness, chromosomal instability and tumor immunity, with a focus on colorectal cancer. He has uncovered a pro-tumorigenic mechanism generating chromosomal instability via whole-genome duplication and has demonstrated that cancer stem cells often display chromosome overload and chromosomal instability.

See recent major publications:

Intratumoral heterogeneity in cancer progression and response to immunotherapy.

Vitale I, Shema E, Loi S, Galluzzi L. Nat Med. 2021 Feb;27(2):212-224. doi: 10.1038/s41591-021-01233-9. Epub 2021 Feb 11. PMID: 33574607 Review.

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.

Manic G, et al. Cell Death Differ. 2021 Jul;28(7):2060-2082. doi: 10.1038/s41418-020-00733-4. Epub 2021 Feb 2. PMID: 33531658 Free PMC article.

CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.

Manic G, et al. Gut. 2018 May;67(5):903-917. doi: 10.1136/gutjnl-2016-312623. Epub 2017 Apr 7. PMID: 28389531 Free PMC article.