From the M1/M2 paradigm, to spatial determinism of tumor-associated macrophageheterogeneity

This presentation proposes that TAM heterogeneity and functions are determined by their
origin and localization in distinct tumor sub-anatomic niches and challenges the association
with the M1/M2 binary model.

BOISSONNAS Alexandre, Principal Investigator- (Directeur de recherche Inserm)
Team leader “Spatio-temporal organization and regulation of myeloid cells” STORM.”
Institut Mondor de Recherche Biomédicale IMRB U955, Université Paris-Est Créteil.

Alexandre Boissonnas is an immunologist and Research Director at the French National Institute of Health and Medical Research (Inserm). He obtained his PhD in 2004, during which he investigated the role of antigen in the homeostasis of peripheral T lymphocytes. He then joined Sébastien Amigorena’s laboratory at Institut Curie, Paris, where he developed innovative two-photon live imaging approaches to study leukocyte migratory behavior in vivo. 

In 2009, he was recruited by Inserm at CIMI-Paris where he established and has since led his own research team focusing on monocyte and macrophage biology. He recently moved to IMRB in Créteil, continuing his investigations on the dynamics of the mononuclear phagocyte system in inflammatory diseases and cancer. His laboratory combines high-dimensional immunomonitoring with advanced imaging technologies to unravel the spatio-temporal organization and regulation of the macrophage compartment, as well as its responses to tissue injury and neoplastic transformation.