Metabolism, Cancer and Immunity
Director :
Guido Kroemer
The team is interested in the triangulation between metabolism (with emphasis on metabolic syndrome, obesity and nutrition), cancer (especially the common cancers: colon, lung and breast) and immunity (and the link between anti-cancer immunosurveillance and autoimmunity) by following the arrow of time, aging
LEGEND: Paradigm shifts in cancer research and therapy. Progress in cancer research is shown in steps, from left to right. A purely cancer-cell-centric view of the tumor (a) has given way to an ever more refined view of neoplasia, with the inclusion of stromal elements (b) and myeloid and lymphoid cells participating in immunosurveillance (c). More recently, the influence of extratumoral effects on cancer biology has been realized (d). The future of oncology relies on the view of cancer as an ecosystem, requiring the simultaneous study of all constituents, as well as their functional interactions.
Main publications
Bodywide ecological interventions on cancer. Kroemer G, McQuade JL, Merad M, André F, Zitvogel L. Nat Med. 2023 Jan;29(1):59-74. doi: 10.1038/s41591-022-02193-4. Epub 2023 Jan 19. PMID: 36658422. link*
ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis. Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, Martins I, Kroemer G. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207344119. doi: 10.1073/pnas.2207344119. Epub 2022 Oct 3. PMID: 36191214; PMCID: PMC9565466. link
Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage. Fluckiger A, Daillère R, Sassi M, Sixt BS, Liu P, Loos F, Richard C, Rabu C, Alou MT, Goubet AG, Lemaitre F, Ferrere G, Derosa L, Duong CPM, Messaoudene M, Gagné A, Joubert P, De Sordi L, Debarbieux L, Simon S, Scarlata CM, Ayyoub M, Palermo B, Facciolo F, Boidot R, Wheeler R, Boneca IG, Sztupinszki Z, Papp K, Csabai I, Pasolli E, Segata N, Lopez-Otin C, Szallasi Z, Andre F, Iebba V, Quiniou V, Klatzmann D, Boukhalil J, Khelaifia S, Raoult D, Albiges L, Escudier B, Eggermont A, Mami-Chouaib F, Nistico P, Ghiringhelli F, Routy B, Labarrière N, Cattoir V, Kroemer G*, Zitvogel L*. (*Co-corresponding authors). Science. 2020 Aug 21;369(6506):936-942. doi: 10.1126/science.aax0701. PMID: 32820119. link
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez- Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. Cell Metab. 2019 Dec 3;30(6):1171. doi: 10.1016/j.cmet.2019.10.011. Erratum for: Cell Metab. 2019 Oct 1;30(4):754-767.e9. PMID: 31801056. link
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G*, Zitvogel L*. (*Co-corresponding authors). Science. 2018 Jan 5;359(6371):91-97. doi: 10.1126/science.aan3706. Epub 2017 Nov 2. PMID: 29097494. link
All publications