Laboratory of Integrative Cancer Immunology
Director :
Jérôme Galon
We aim to understand tumor progression and immune reaction against cancer from pre-cancerous lesion to metastasis by using integrative biology and bioinformatics, to improve the immunotherapeutic management of cancer patients. Our research projects are focusing on the analysis of the pre-existing immunity and its modulation.
Key Words: Tumor, Immune, Bioinformatics, Integration
Immunoscore quantification. CD3 chromogenic staining on colorectal tumor tissue by IHC.(left).Characterization of the tumor immune microenvironment. Multiplexed imaging of colorectal tumor tissue: DAPI (blue), CD3 (green), CD8 (red), FoxP3 (yellow), Neutrophil elastase (white), CD68 (magenta) and Cytokeratin (cyan) (right)
Comparison tumor vs normal colon tissue. CyTOF analysis – Clustering using UMAP
Main publications
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer. Mlecnik B, Bifulco C, Bindea G, Marliot F, Lugli A, Lee JJ, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Lafontaine L, Bruni D, Lanzi A, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Paustian C, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Muşină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Fox BA, Pagès F, Galon J*. J Clin Oncol. 2020 Sep 8:JCO1903205. link
Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study. Pagès F, André T, Taieb J, Vernerey D, Henriques J, Borg C, Marliot F, Ben Jannet R, Louvet C, Mineur L, Bennouna J, Desrame J, Faroux R, Kirilovsky A, Duval A, Laurent-Puig P, Svrcek M, Hermitte F, Catteau A, Galon J*, Emile JF*. Ann Oncol. 2020 Apr 12:S0923-7534(20)36415-2. link
Tumor Immunology and Tumor Evolution: Intertwined Histories. Galon J*, Bruni D. Immunity, 2020 Jan 14, 52 (1), 55-81 link
The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Bruni D, Angell HK, Galon J*.Cancer. 2020 Nov;20(11):662-680. link
All publications
