Vascular integration in tissue bioengineering to model the complexity of leukemic microenvironment

Summury

We investigate the dynamic interactions between leukemic cells and their vascular microenvironment. Combining in vivo imaging, humanized 3D models, and multi-omics approaches, we explore how the niche contributes to leukemia progression, treatment resistance, and immune evasion, particularly in the bone marrow and central nervous system.