19/01/2024
The CRC is to benefit from a Sorbonne University Junior Professorship, which will be open to competition in spring 2024 for recruitment at the end of 2024.
The CRC, a nationally and internationally recognized multidisciplinary center of excellence headed by Professor Jessica Zucman-Rossi, comprises 16 teams and 4 high-level technology platforms (www.crcordeliers.fr) developing research projects in oncology, immunology, bioinformatics and pathophysiology. Scientific projects are part of a continuum between fundamental, translational and clinical research.
The CRC is looking to recruit a junior professor to strengthen the multidisciplinary and innovative aspects of the excellent cancer research currently being developed.
CRC will provide the successful candidate with suitable laboratory and office space. The research group will benefit from access to CRC scientific platforms (cytometry, conventional and spatial imaging, metabolism, bioinformatics, digital PCR, animal facility, biobank, etc.) and shared services. The group will benefit from financial support from CRC (€20K/year) and mentoring from a CRC team, in particular for assistance with funding applications, recruitment and career management, teaching and student supervision.
To apply, send a CV and covering letter to :
jessica.zucman-rossi@inserm.fr and catherine.dastier@sorbonne-universite.fr
- Scientific orientations of the research project
Understanding the mechanisms of initiation and progression of carcinogenesis must take into account the cellular microenvironment and the cell of origin in the context of the individual as a whole, with his or her genetic baggage and lifelong environmental exposures (carcinogens, diets, viral infections, radiation, etc.). The Centre de Recherche des Cordeliers is looking to recruit a young researcher for a Junior Professorship to strengthen its strategy of multi-scale integration of the biological mechanisms involved in carcinogenesis processes, integrating host and exposure factors to identify the mechanisms of initiation, progression and therapeutic response of cancer pathologies. Different approaches will be considered in biology (immunology, genomics, mechanisms of proliferation and cell death, etc.) and/or bioinformatics (development of integrative data analysis approaches).
The first level is the study of the interaction between individuals’ lifelong exposure to toxic substances, the effects of which are modulated by genetic polymorphisms and the individual immunological context. To this end, CRC projects benefit from large cohorts of cancer patients (digestive and ENT tracts, lungs, kidneys, etc.) for combined studies of clinical, genetic and exposure variables. The early stages of carcinogenesis are particularly important for understanding the early mechanisms of malignant transformation, and ultimately improving prevention and early detection.
The second level is the study, on a cellular scale, of interactions between tumor cells and those of the microenvironment in the vicinity of the tumor and throughout the organism. With the development of immunotherapy, for which CRC teams have helped lay the foundations, the study of the anti-tumor immune response and how to modulate this response is essential to understanding the mechanisms of sensitivity/resistance, and ultimately to improving these immunomodulatory treatments by taking into account the different molecular subtypes of cancers.
The third level of study consists of integrating all the data from cancer patients – data from a variety of sources, including clinical, historical, biological, molecular, genomic, genetic and phenotypic (ultra-multiplexed imaging, spatial transcriptomics, etc.) – to identify new evolutionary models, model them and identify new therapeutic targets.
We are looking for a teacher-researcher developing innovative approaches in one or more of these areas of study, who can establish collaborations with CRC research teams to advance our knowledge in this field, but also to develop new therapeutic tools and original techniques for integrated analysis of heterogeneous data, enabling us to make rapid progress.
- Planned integration into teaching
The research theme will fit in with several teaching areas of Sorbonne University’s Life Sciences UFR, depending on the training of the researcher recruited, particularly in the fields of immunology, oncology and cell biology in general. The junior professor may also be involved in bioinformatics, in the development of new integrated analyses of biological data in AI, (imaging, genomics etc…), in themes linked to environmental exposure, virology with specific approaches to data integration of the “One Health” type. Participation in teaching will take place at several possible levels of the LMD curriculum, in doctoral schools and DUs, with the support and supervision of the CRC’s many teacher-researchers, in close collaboration with the UFR’s teaching council. The junior professor will also be involved in training pre-doctoral and thesis students in the laboratory.