Molecular pathways involved in autosomal dominant polycystic kidney disease progression

PARIS POSTDOCS SEMINAR

In 2018, I obtained my Master of Science diploma in Biochemistry and Molecular Genetics at the Faculty of Medicine of the Université de Montréal, Canada. As part of my Master’s research, I worked for over two years in the Molecular Genetics and Development group of Dr Marie Trudel at the Montreal Clinical Research Institute (IRCM). I developed an interest in genetic kidney diseases while working on autosomal dominant polycystic kidney disease (ADPKD), particularly on the signaling and intracellular interactions of polycystin-1. My wish to extend my research on inherited kidney disorders led me to enroll in a PhD in the Integrative Molecular Medicine program at the University of Zurich, Switzerland, where I joined the Mechanisms of Inherited Kidney Disorders group of Prof Olivier Devuyst at the Institute of Physiology. From May 2018 until December 2022, my PhD work focused on autosomal dominant tubulointerstitial kidney disease caused by mutations in UMOD (ADTKD-UMOD). Using powerful mouse models, my research aimed to understand the pathogenic mechanisms in ADTKD-UMOD, including identifying new targets and therapeutic approaches. My desire to pursue translational research in chronic kidney disease led me to join the group of Dr Fabiola Terzi on Mechanisms and Therapeutic Strategies of Chronic Kidney Disease at INEM in January 2023. My research is now focused on the molecular pathways involved in ADPKD progression by taking advantage of established ADPKD mouse models and a urine biobank of ADPKD patients