See all job offers and internship opportunities at CRC.
Post-doc position on influenza vaccine – Dec. 21
Influenza is a major health burden with an estimated 500,000 deaths annually and many more diseased people. A pandemic with influenza virus could affect millions of people world-wide and disrupt society as seen with the SARS-CoV pandemic in 2003 and SARS-CoV-2 in 2020. Despite the relatively small number of affected subjects and case-fatality rate of 11%, the impact (economic losses) were enormous. Pandemic flu has much greater potential for spread than SARS and is likely to have a greater impact on health and disruption of the global economy. What starts with a relatively simple flu infection, may evolve to a serious or fatal secondary infection of the respiratory tract. Some people are more likely to develop severe illness, especially elderly, children ≤5 years, chronically diseased people, and pregnant women. Flu vaccination is the best way to prevent serious complications and death caused by flu.
This position is open in the team Immunopathology and Therapeutic Immuno-intervention, as part of the EU H2020-India DBT project, under supervision of Jagadeesh Bayry.
Abstract of the project
From a global health perspective, the lack of effectivity, availability, affordability and accessibility of flu vaccines significantly limits our ability to respond to the seasonal flu every year and in the event of a pandemic. Currently, a low vaccine effectivity of 40% implies that 60% of vaccinated people are not sufficiently protected, with low confidence further contributing to limited uptake/immunization.
In this EU H2020-India DBT project, our aim is to develop next generation influenza vaccines with low antigen dose and low cost to elicit optimal, robust and durable antibody responses by using novel generation adjuvants and recombinant influenza antigens devoid of immunosuppressive domains. The consortium includes 9 teams from Europe, one from USA and 6 teams from India.
The initial offer is for one year but can be extended further depending on the progress. Salary is based on the experience of the candidate.
Main activities
– Immune cell isolation from the human blood, mice, primary cell culture
– In vivo experiments in mice
– Use of techniques such as various immune cell isolation techniques, flow cytometry, cell sorting, ELISA, western blot, RT-qPCR and other regular techniques
– Actively supporting the other research activities of the group (in particular, ANR funded basophil project)
– Reporting the data, preparation of project reports, writing the articles
Associated activities
– Mastering the biology techniques of the experimental field
– Write technical procedures
– Control the storage conditions of biological samples
– Planning the experiments, ordering the materials
– Work in a confined environment or in a protected area
– interaction with team members
Experience required
- Experience in immunology
- Techniques such as flow cytometry, specific immune cell isolation, ELISA, Western Blot, RT-qPCR, molecular biology techniques
- Knowledge on the bioinformatics, statistics
Deadline: Opening is immediate. Due to the pandemic, we are preferring the candidates from France or neighboring EU countries to avoid delays in administration.
Application: please send CV to Jagadeesh BAYRY (Jagadeesh.bayry@crc.jussieu.fr)
PhD position in Jessica Zucman Rossi’s team – Juil. 21
A 3-year doctoral position, funded by a Cifre grant of Sanofi, is available in the team “Functional Genomic of Solid Tumor,” headed by Jessica Zucman-Rossi.
Starting early fall 2021, a 3-year PhD student position financed by a Cifre grant from Sanofi is available at the Cordeliers Research Center in the “Functional Genomics of Solid Tumors” (FunGeST) team led by Jessica Zucman-Rossi under the supervision of Didier Jean.
Subject: Better understand and characterize the role of TEAD proteins in malignant pleural mesothelioma tumors.
Application: Applicants should send their CV, letter of motivation and name of references to Didier Jean: didier.jean@inserm.fr
Deadline: Position available beginning of Autumn 2021, apply as soon as possible
Post-doc position on interaction between human regulatory T cells and basophils – Avril 21
A one-year renewable post-doc position is available in the lab “Immunopathology and Therapeutic Immuno-intervention” at CRC.
Abstract of the project
Basophils, although rare, play a key role in the initiation and propagation of allergic diseases. It is therefore conceivable that basophils are potential therapeutic targets for allergic diseases. However, there is currently no specific approach to target them. Since IL-3, secreted mainly by T cells, is the most potent activator of basophils, we propose to finely dissect the IL-3 axis in various facets of human T cell-basophil crosstalk in vitro, in situ in allergic patients, and in vivo in genetically engineered mouse models. In addition, in a translational research setting, we will interfere with the IL-3 axis as a novel means to inhibit basophil activation and treat allergic diseases. This ANR funded project involves four partners and the objective of our group, as project coordinator, is to dissect the interaction between human regulatory T cells and basophils at the cellular and molecular level. This is a follow-up to our report published in Science Immunology (2018). (https://immunology.sciencemag.org/content/3/23/eaan0829.long)
Duration: The initial offer is for one year but can be extended for an additional year based on progress.
Salary: Up to 56 k€ based on the candidate’s experience. Candidates with up to 4 years of post-doc experience are sought.
Main activities
– Immune cell isolation from human blood and primary cell culture
– Use of techniques such as various immune cell isolation techniques, flow cytometry, cell sorting, ELISA, western blot, RT-qPCR and other regular techniques
– Active support of the other research activities of the group (in particular, ongoing EU project on flu vaccine and ANR funded COVID project)
– Data Reporting, preparation of project reports, writing of the articles
Associated activities
– Write technical procedures
– Control the storage conditions of biological samples
– Plan the experiments, order the materials
– Work in a confined environment or in a protected area
– interaction with team members
Experience required
– Experience in human immunology
– Mastering the biology techniques of the experimental field
– Techniques such as flow cytometry, specific immune cell isolation, ELISA, Western Blot, RT-qPCR, molecular biology techniques
– Knowledge in bioinformatics
Deadline for application: Opening is immediate. Due to pandemic, candidates from France or neighboring EU countries are preferred to avoid administrative delays.
To apply: please send CV and letter of motivation to:
Jagadeesh BAYRY: Jagadeesh.bayry@crc.jussieu.fr
Three-year post-doc position in tumor immunology – Mars 21
The Laboratory of Integrative Cancer Immunology, headed by Jérôme Galon is offering a 3-year post-doc position in tumor immunology.
Applicants must have a strong background in the field of Immunology. The applicant should have good knowledge of biology, particularly in the field of cancer.
A previous experience with large-scale approaches, flow cytometry/CyTOF, immunohistochemistry is sought; knowledge of imaging techniques and/or statistics is a plus. The project will involve a close cooperation with other biologists and bioinformaticians.
This position is financed through a post-doctoral grant obtained by the laboratory (INSERM, Paris, France).
This is a three-year postdoctoral position, to be filled as soon as possible.
About the employer:
Dr Jérôme Galon is Research Director at INSERM and head of the Laboratory of Integrative Cancer Immunology at the Cordeliers Research Centre (Sorbonne University, Paris, France) specialized in the fields of Immunology and Oncology. He is associate Director and co-founder of European Academy of Tumor Immunology (EATI), board member of Society for Immunotherapy of Cancer (SITC). His work on the comprehensive analysis of the tumor-microenvironment and the role of T-cells in human cancer led to the demonstration of the importance of adaptive pre-existing immunity in human cancer, and the concept of cancer immune-contexture. He pioneered the Immunoscore. He is the co-founder of HalioDx company and the Chairman of its scientific council. His contributions have been recognized with numerous awards, including the William B. Coley Award, an international prize which honors the best scientists in the fundamental and cancer immunology, and Award from the National Academy of Science and from the National Academy of Medicine.
Two-year Postdoctoral Position in Immunology and Molecular Cell Biology of liver metabolic diseases – Mars 21
Starting in June 2021, a 2-year post-doctoral position is available in the team “Proliferation, Stress and Liver Physiopathology” led by Chantal Desdouets.
Starting in June 2021, a 2-year post-doctoral position funded by INCa is available at the Centre de Recherche des Cordeliers in the team “Proliferation, Stress and Liver Physiopathology” led by Chantal Desdouets.
We are looking for an experienced, highly independent, and dynamic candidate willing to drive an ambitious project in the understanding of how DNA damage response and immunosurveillance impact on hepatocytes cell division and transformation leading to hepatocellular carcinoma (HCC) under metabolic disorders. Of note, HCC has one of the worst survival rate of all cancers and alarmingly, obesity epidemic will particularly accentuate its incidence. The project involves already established collaborations, including clinical teams in hepatology and pathology departments, and the use of cutting-edge technologies. The applicant will benefit from a highly collaborative and diverse environment at the Centre de Recherche des Cordeliers and from state-of-the-art technological platforms. The Centre de Recherche des Cordeliers is located in the center of Paris in a culturally and scientifically rich environment.
Candidates with a PhD in onco-immunology and solid background in cellular and molecular biology are strongly encouraged to apply. Work with murine models (accreditation for animal experimentation (Level 1)) is required. A previous experience in metabolism and/or in bioinformatics analyses would be an advantage. The candidate should be fluent in English, is expected to show independent thinking and ability to drive its own research, and to be willing to participate to the lab’s life.
Application: Applicants should send their CV, letter of motivation and name of 2 references to Chantal Desdouets: chantal.desdouets@inserm.fr
Deadline: Position available now. Apply as soon as possible.
Research Project manager – Sept. 20
We have an exciting opportunity to join our team as a Research Project Manager. In this role, the successful candidate is reporting to the Director of the laboratory, Jérôme Galon. The Research Project Manager will be responsible for providing a broad range of complex project management services across multiple research studies in the lab.
Administrative management assistant – June 20
To provide the administrative secretariat and the management of the credits and resources of one or more research teams, ensuring compliance with the rules and procedures applicable to the various supervisory authorities on which the research team depends.
Post-doc position at CRC for Covimune Project – June 20
(Posted June 18, 2020)
The CRC is involved in the COVIMUNE project, dedicated to studying the immune crosstalk during Covid19 infection. A post-doc position is open for 1 year, shared by CRC and Pasteur Institute, to work on this project. Deadline for application: July 15, 2020
Mobility offer for a research engineer in immunology and animal experimentation – June 20
(Posted JUNE 2020)
The design engineer will join a dynamic research team in immuno-cancerology, within the Cordeliers Research Center, whose projects focus on the study of the tumor immune microenvironment, using patient cohorts and animal models. Offer from the University of Paris.
Job description
Inserm internal mobility zootechnician position – June 20
(Posted June 2020)
The technician in animal husbandry and production techniques and in animal experimentation techniques takes care of the animals, and he/she implements and adapts pre-established processes of breeding or maintenance of animal lines and implements by adapting them experimental protocols.